SML2530

CAY10526

≥98% (HPLC)

• Synonym(s): 4-(Benzo[b]thiophen-2-yl)-3-bromo-5-hydroxyfuran-2(5H)-one, 4-Benzo[b]thien-2-yl-3-bromo-5-hydroxy-2(5H)-furanone, 4-Benzo[b]thiophen-2-yl-3-bromo-5-hydroxy-5H-furan-2-one
• Empirical Formula (Hill Notation): C₁₂H₇BrO₃S
• CAS Number: 938069-71-7
• Molecular Weight: 311.15
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C1OC(C(C2=CC3=C(S2)C=CC=C3)=C1Br)O
• InChI: 1S/C12H7BrO3S/c13-10-9(11(14)16-12(10)15)8-5-6-3-1-2-4-7(6)17-8/h1-5,11,14H
• InChI key: ICCDILPNCJIDAW-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CAY10526 is a selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) expression. CAY10526 potently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells. CAY10526 significantly suppressed tumor growth and increased apoptosis in melanoma xenografts.

selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) expression that potently inhibits PGE2 production

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable