SML0769

Cu-ATSM

≥98% (HPLC), peroxynitrite inhibitor, powder

• Synonym(s): Cu^II(ATSM), Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II), [[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
• Empirical Formula (Hill Notation): C₈H₁₄CuN₆S₂
• CAS Number: 68341-09-3
• Molecular Weight: 321.91
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Cu-ATSM, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: , brown to dark red-brown
• solubility: DMSO: 0.5 mg/mL, clear (warmed)
• storage temp.: 2-8°C

Description

Biochem/physiol Actions

Cu-ATSM is an orally bioavailable, blood-brain barrier permeable complex that specifically inhibits the action of peroxynitrite on Cu,Zn superoxide dismutase (SOD1) and subsequent nitration of cellular proteins. Cu^II(ATSM) significantly delayed onset of disease (paralysis and prolonged lifespan) in amyotrophic lateral sclerosis (ALS) mice model. Also, Cu-ATSM was reported to lower lipid peroxidation in a model of ischemicreperfusion injury. Cu-ATSM subsequently was shown to inhibit ferroptosis with a potency similar to Liproxstatin-1.

Cu-ATSM is an orally bioavailable, blood-brain barrier permeable complex that specifically inhibits the action of peroxynitrite on Cu,Zn superoxide dismutase (SOD1).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable