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SML0720

Methazolamide

≥98% (HPLC), carbonic anhydrase inhibitor, powder

Synonym(s):

5-Acetylimino-4-methyl-·2-1,3,4-thiadiazoline-2-sulfonamide, N-(4-Methyl-2-sulfamoyl-Δ2-1,3,4-thiadiazolin-5-ylidene) acetamide, L 584601, N-[5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide

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About This Item

Empirical Formula (Hill Notation):
C5H8N4O3S2
CAS Number:
Molecular Weight:
236.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
209-066-7
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
protect from light
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Product Name

Methazolamide, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

mp

208 °C (dec.) (lit.)

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN1N=C(S\C1=N\C(C)=O)S(N)(=O)=O

InChI

1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+

InChI key

FLOSMHQXBMRNHR-QPJJXVBHSA-N

Gene Information

Biochem/physiol Actions

Cell-permeable and potent carbonic anhydrase (CA) inhibitor
Methazolamide is a cell-permeable and potent carbonic anhydrase (CA) inhibitor that is used in the treatment of glaucoma. Methazolamide is an insulin sensitizer that reduces hepatic glucose generation in animal models.
Methazolamide has a plasma half-life of 14 hours in humans. Methazolamide has relatively good lipid solubility and low plasma protein binding ability. Thus, it diffuses into tissues and fluids much more readily than acetazolamide, another carbonic anhydrase inhibitor. Methazolamide has less side effects than acetazolamide.

Other Notes

Light sensitive

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This Item
1406005SML2472PHR3202
form

powder

form

-

form

powder

form

-

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

300

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-30°C

storage condition

protect from light

storage condition

-

storage condition

-

storage condition

-

solubility

DMSO: 20 mg/mL, clear

solubility

-

solubility

DMSO: 2 mg/mL, clear

solubility

-


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pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3



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