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About This Item
Empirical Formula (Hill Notation):
C5H8N4O3S2
CAS Number:
Molecular Weight:
236.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
209-066-7
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
protect from light
Pricing and availability is not currently available.
Product Name
Methazolamide, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white to beige
mp
208 °C (dec.) (lit.)
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
CN1N=C(S\C1=N\C(C)=O)S(N)(=O)=O
InChI
1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+
InChI key
FLOSMHQXBMRNHR-QPJJXVBHSA-N
Biochem/physiol Actions
Cell-permeable and potent carbonic anhydrase (CA) inhibitor
Methazolamide is a cell-permeable and potent carbonic anhydrase (CA) inhibitor that is used in the treatment of glaucoma. Methazolamide is an insulin sensitizer that reduces hepatic glucose generation in animal models.
Methazolamide has a plasma half-life of 14 hours in humans. Methazolamide has relatively good lipid solubility and low plasma protein binding ability. Thus, it diffuses into tissues and fluids much more readily than acetazolamide, another carbonic anhydrase inhibitor. Methazolamide has less side effects than acetazolamide.
Other Notes
Light sensitive
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This Item | |||
|---|---|---|---|
| form powder | form - | form powder | form - |
| assay ≥98% (HPLC) | assay - | assay ≥98% (HPLC) | assay - |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level 300 |
| storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C | storage temp. 2-30°C |
| storage condition protect from light | storage condition - | storage condition - | storage condition - |
| solubility DMSO: 20 mg/mL, clear | solubility - | solubility DMSO: 2 mg/mL, clear | solubility - |
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
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