SML0418

ML-161

≥98% (HPLC)

• Synonym(s): 2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]-benzamide
• Empirical Formula (Hill Notation): C₁₇H₁₇BrN₂O₂
• CAS Number: 423735-93-7
• Molecular Weight: 361.23
• MDL number: MFCD03063772
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825413
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL (clear solution)
• storage temp.: 2-8°C
• SMILES string: CCCC(=O)Nc1cccc(NC(=O)c2ccccc2Br)c1
• InChI: 1S/C17H17BrN2O2/c1-2-6-16(21)19-12-7-5-8-13(11-12)20-17(22)14-9-3-4-10-15(14)18/h3-5,7-11H,2,6H2,1H3,(H,19,21)(H,20,22)
• InChI key: DFOVLSMXPWPCFH-UHFFFAOYSA-N

Description

Biochem/physiol Actions

ML-161 is an antagonist of the protease-activated receptor 1 (PAR1), that inhibits thrombin and SFLLN-induced platelet activation. ML-161 dose dependently inhibits SFLLN-induced expression of P-selectin with an IC₅₀ of 0.26 μM.

Safety Information

• Pictograms: GHS09
• Signal Word: Warning
• Hazard Statements: H410
• Precautionary Statements: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable