S5576

SKA-31

≥98% (HPLC)

• Synonym(s): Naphtho[1,2-d]thiazol-2-ylamine
• Empirical Formula (Hill Notation): C₁₁H₈N₂S
• CAS Number: 40172-65-4
• Molecular Weight: 200.26
• NACRES: NA.25
• PubChem Substance ID: 329824457
• UNSPSC Code: 12352202
• MDL number: MFCD00051329
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: ≥30 mg/mL
• storage temp.: −20°C
• SMILES string: Nc1nc2c(ccc3ccccc23)s1
• InChI: 1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)
• InChI key: FECQXVPRUCCUIL-UHFFFAOYSA-N

Description

Biochem/physiol Actions

SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels.

SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC₅₀ is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice, suggesting potassium channel activation as a therapeutic target for hypertension.

SKA31 is an activator of KCa2 and KCa3.1

SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H319
• pcodes: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable