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O5507

Sigma-Aldrich

Linoleic acid, conjugated

Synonym(s):

CLA, Octadecadienoic acid, conjugated

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.77
Pricing and availability is not currently available.

impurities

≤1% Linoleic acid

Quality Level

100

lipid type

omega FAs

storage temp.

−20°C

General description

A mixture of cis- and trans-9,11- and -10,12-octadecadienoic acids. Isomer ratio may vary from lot to lot.

Application


  • A targeted nanomodulator capable of manipulating tumor microenvironment against metastasis.: The paper discusses the development of a targeted nanomodulator, including conjugated linoleic acid, to manipulate the tumor microenvironment and inhibit metastasis. The findings suggest significant potential for improved cancer treatments (Tian et al., 2022).

  • Hyaluronic Acid-Modified Nanoparticles Self-Assembled from Linoleic Acid-Conjugated Chitosan for the Codelivery of miR34a and Doxorubicin in Resistant Breast Cancer.: The research focuses on hyaluronic acid-modified nanoparticles using linoleic acid-conjugated chitosan for the codelivery of miR34a and doxorubicin. This approach aims to overcome drug resistance in breast cancer treatments (Yang et al., 2022).

Biochem/physiol Actions

Potent inhibitor of breast, skin, and colon carcinogenesis and tumor cell proliferation; inhibits bFGF-induced endothelial cell proliferation; potent antioxidant.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW0137
MKCT6997
MKCT7623
MKCQ0895
MKCP5797

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Atique A Behan et al.
Animals : an open access journal from MDPI, 9(7) (2019-07-03)
Rumen protected fats (RPF) are known to improve animal performance without affecting rumen metabolism in sheep. However, comparative effects of prilled fat, prilled fat with lecithin and calcium soap have not been fully studied. Hence this experiment was planned using
Martha A Belury
The Journal of nutrition, 132(10), 2995-2998 (2002-10-09)
Conjugated linoleic acid (CLA) is composed of positional and stereoisomers of octadecadienoate (18:2); it is found in foods derived from ruminants (beef and lamb as well as dairy products from these sources). When a mixture of isomers is fed to
Swati Shivani et al.
Journal of the science of food and agriculture, 96(5), 1716-1722 (2015-05-29)
Conjugated linoleic acid (CLA) isomers have high health amelioration potential and hence it is of great interest to increase the CLA content in dairy products. The present study was conducted to investigate the effect of administration of high CLA producing
Rui Guo et al.
Frontiers in nutrition, 9, 1026740-1026740 (2022-11-01)
Dietary fat composition is closely associated with the pathological development of alcoholic liver disease (ALD). Fat enriched with saturated fatty acids protects whereas with polyunsaturated fatty acids aggravates alcohol-induced liver injury. However, limited study has addressed how monounsaturated fatty acids
Christina Donnelly et al.
Nutrition and cancer, 61(1), 114-122 (2009-01-01)
Spot 14 (THRSP, S14) is a nuclear protein involved in the regulation of genes required for fatty acid synthesis in normal and malignant mammary epithelial and adipose cells. Harvatine and Bauman (1) reported that conjugated linoleic acid (CLA) inhibits S14
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Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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