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Netropsin dihydrochloride

Name: Netropsin dihydrochloride
Brand: SIGMA

From Streptomyces netropsis, ≥98% (HPLC), powder

Synonym(s):

Congocidin, Sinanomycin

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₆N₁₀O₃ · 2HCl

CAS Number:

18133-22-7

Molecular Weight:

503.39

UNSPSC Code:

12352200

PubChem Substance ID:

24897909

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

Netropsin dihydrochloride, from Streptomyces netropsis, ≥98% (HPLC), powder

biological source

Streptomyces netropsis

Quality Segment

200

assay

≥98% (HPLC)

form

powder

color

faintly yellow

solubility

H₂O: 1 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, viruses

mode of action

DNA synthesis | interferes

storage temp.

−20°C

SMILES string

[H]Cl.[H]Cl.NC(CCNC(C1=CC(NC(C2=CC(NC(CNC(N)=N)=O)=CN2C)=O)=CN1C)=O)=N

InChI

1S/C18H26N10O3.2ClH/c1-27-9-11(6-12(27)16(30)23-4-3-14(19)20)26-17(31)13-5-10(8-28(13)2)25-15(29)7-24-18(21)22;;/h5-6,8-9H,3-4,7H2,1-2H3,(H3,19,20)(H,23,30)(H,25,29)(H,26,31)(H4,21,22,24);2*1H

InChI key

SDRHUASONSRLFR-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Netropsin is an unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G.

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Protect from light.

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This Item	N2001	N7758	SML1823
Sigma-Aldrich N9653 Netropsin dihydrochloride	Sigma-Aldrich N2001 Neostigmine bromide	Sigma-Aldrich N7758 Naloxone hydrochloride dihydrate	Sigma-Aldrich SML1823 Vosaroxin hydrochloride
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC and titration)	assay ≥98% (TLC and titration)	assay ≥98% (HPLC)
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 100
storage temp. −20°C	storage temp. -	storage temp. 2-8°C	storage temp. −20°C
solubility H₂O: 1 mg/mL	solubility H₂O: 1 g/mL, ethanol: soluble	solubility ethanol: 3.3 mg/mL, H₂O: 50 mg/mL	solubility H₂O: 1 mg/mL, clear (warmed)
color faintly yellow	color white	color white to off-white	color white to beige

Storage Class

11 - Combustible Solids

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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