Yes, DMSO can be added directly to the vial. It is recommended to pipet up and down a few times to ensure that all the material is solubilized in DMSO.
M6191
GW9662
>98% (HPLC), PPARγ antagonist, powder
Synonym(s):
2-Chloro-5-nitro-N-phenylbenzamide
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About This Item
Empirical Formula (Hill Notation):
C13H9ClN2O3
CAS Number:
Molecular Weight:
276.68
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Pricing and availability is not currently available.
Product Name
GW9662, >98% (HPLC)
Quality Level
assay
>98% (HPLC)
form
powder
color
white
solubility
DMSO: 26 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
[O-][N+](=O)c1ccc(Cl)c(c1)C(=O)Nc2ccccc2
InChI
1S/C13H9ClN2O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,(H,15,17)
InChI key
DNTSIBUQMRRYIU-UHFFFAOYSA-N
Gene Information
human ... PPARG(5468)
Application
GW9662 has been used as a peroxisome proliferator activated receptor γ (PPARγ) antagonist in human pluripotent stem cells, in phenylephrine stimulated cardiomyocytes and to inhibit the protective effect of telmisartan pheochromocytoma, PC12 cells.[1]
Biochem/physiol Actions
GW9662 is an irreversible PPARγ antagonist. GW9662 inhibits connective tissue growth factor and activation of CD36 by IL-4.
GW9662 is an irreversible PPARγ antagonist; inhibits connective tissue growth factor, and activation of CD36 by IL-4.
GW9662 (2-chloro-5-nitrobenzanilide) binds to the ligand binding site of the peroxisome proliferator activated receptor γ (PPARγ) and results in the inhibition of adipocyte differentiation. It favors cell growth suppression in breast cancer cell lines even in the presence of PPARγ agonist rosiglitazone. It stimulates M2c macrophages differentiation and triggers growth arrest-specific 6 (Gas6) expression. GW9662 co treatment with other PPARγ ligands elicits antiproliferative effects on the glioblastoma stem cells and could be a potent therapeutic agent.
Features and Benefits
This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Legal Information
Sold for research purposes only, under agreement from GlaxoSmithKline
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This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay >98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 26 mg/mL, H2O: insoluble | solubility DMSO: >20 mg/mL | solubility DMSO: ≥10 mg/mL | solubility DMSO: 2 mg/mL, clear |
| color white | color off-white to tan | color white to off-white | color faint yellow to dark orange |
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Related Content
Efstathia Papageorgiou et al.
Molecular medicine (Cambridge, Mass.), 14(7-8), 403-411 (2008-05-14)
PPARgamma, a member of the peroxisome proliferator-activated receptor family, is overexpressed in prostate cancer. Natural and synthetic ligands of PPARgamma via genomic and nongenomic actions promote cell cycle arrest and apoptosis of several prostate cancer cells, in vitro. Insulin-like growth
The PPAR-gamma antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-gamma in human macrophage polarization
Zizzo G and Cohen PL
Journal of Inflammation, 12(1), 36-36 (2015)
GW9662, a potent antagonist of PPARgamma, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARgamma agonist rosiglitazone, independently of PPARgamma activation
Seargent JM, et al.
British Journal of Pharmacology, 143(8), 933-937 (2004)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M6191-25MG | 04061832954561 |
| M6191-5MG | 04061834060758 |
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GW9662 25mg을 구입해서 사용하고 있는데, 혹시 25mg 정량이 담겨져 오는걸까요? powder를 무게 재기 어려워서 그냥 vial에 바로 DMSO를 추가해서 쓸 수 있을까해서요!
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