M5571

Miltefosine

≥98% (perchloric acid titration)

• Synonym(s): Choline hexadecyl phosphate, HePC, Hexadecyl phosphocholine
• Empirical Formula (Hill Notation): C₂₁H₄₆NO₄P
• CAS Number: 58066-85-6
• Molecular Weight: 407.57
• MDL number: MFCD00133396
• UNSPSC Code: 51191904
• PubChem Substance ID: 329818017
• NACRES: NA.85

Properties

• biological source: synthetic (organic)
• description: zwitterionic
• Assay: ≥98% (perchloric acid titration)
• form: powder
• solubility: H₂O: 10 mg/mL, clear, colorless
• functional group: phospholipid
• lipid type: phospholipids
• storage temp.: room temp
• SMILES string: [O-]P(OCC[N+](C)(C)C)(OCCCCCCCCCCCCCCCC)=O
• InChI: 1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3
• InChI key: PQLXHQMOHUQAKB-UHFFFAOYSA-N

Description

Application

• Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents.: This study underlines the necessity for innovative treatments amidst growing resistance to established drugs such as miltefosine which is used as a positive control reference, potentially setting a new direction for antileishmanial drug development (Ciccone et al., 2024).

Biochem/physiol Actions

Inhibitor of protein kinase C and of phosphatidylcholine synthesis. Used for the treatment of visceral and cutaneous leishmaniasis. Active against metronidazole-resistant and -susceptible strains of Trichomonas vaginalis

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves