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H7403

Sigma-Aldrich

Anti-Histamine antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti Histamine Antibody, Histamine Antibody, Histamine Antibody - Anti-Histamine antibody produced in rabbit

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About This Item

MDL number:
MFCD00162380
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

wide range

technique(s)

dot blot: 1:14,000 using histamine-BSA.
immunohistochemistry: 1:100 using 4% paraformaldehyde/4% carbodiimide-fixed or 4% paraformaldehyde-fixed sections of rat stomach

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

General description

Histamine, (2-(4-Imidazolyl)ethylamine), is a widely distributed substance in peripheral tissues. Histamine is localized in mast cells, neuronal cells and neuroendocrine cells of the gastric tract. It is also expressed in lungs, kidney, in cerebrovascular endothelial cells and throughout the peripheral nervous system.

Specificity

The product specifically stains histamine-containing cells in paraformaldehyde/carbodiimide-fixed or paraformaldehyde-fixed, paraffin-embedded sections of rat stomach (endocrine cells and mast cells).

Immunogen

histamine conjugated to succinylated KLH

Application

Anti-Histamine antibody produced in rabbit has been used:
  • in immunohistochemistry
  • to test immunohistochemical reactions of Pseudophoxinus antalyae digestive system tissues
  • in immunocytochemical assays
  • in immunofluorescence assays

Biochem/physiol Actions

Histamine, (2-(4-Imidazolyl)ethylamine) mediates a variety of physiological activities including inflammation, gastric acid secretion and smooth muscle contraction. It is also implicated in modulation of cell growth and differentiation, during embryogenesis, and tumor growth and in the suppression of mitogen-induced lymphocyte proliferation. In the central nervous system (CNS), histamine acts as a neurotransmitter/ neuromodulator of various brain activities.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jonathon L McClain et al.
Biomolecules, 13(11) (2023-11-25)
Histamine is a neuromodulator that affects gut motility and visceral sensitivity through intrinsic and extrinsic neural pathways, yet the mechanisms regulating histamine availability in these pathways remain poorly understood. Here, we show that enteric glia contribute to histamine clearance in
The role of histamine H4 receptor in immune and inflammatory disorders
Zampeli E, et al.
British Journal of Pharmacology, 157, 24-24 (2009)
A Vodenicharov et al.
Anatomia, histologia, embryologia, 34(6), 343-349 (2005-11-18)
Morphological, morphometric, histochemical and immunocytochemical investigations on mast cells, located in the wall of ureter of 8 months aged pigs were performed. Mast cells were found in all three layers of ureteral wall, but their distribution was irregular and the
Immunohistochemical localization of cholecystokinin and histamine in gastrointestinal tract in flower fish
SENOL N, et al.
Experimental Physiology, 1(1), 26-34 (2006)
Jasmin Becker et al.
Frontiers in physiology, 10, 329-329 (2019-04-12)
The density of intestinal mast cells has been reported to increase during inflammatory bowel disease (IBD). As mast cell mediators are known to increase the permeability of epithelial tight junctions, we hypothesized that antigen responses in sensitized animals might be
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