G5779

Gly-Pro-Arg-Pro amide

≥97% (HPLC), Fibrin polymerization inhibitor

• Synonym(s): GPRP amide, Glycine-Proline-Arginine-Proline amide, Glycyl-L-prolyl-L-arginyl-L-prolinamide
• Empirical Formula (Hill Notation): C₁₈H₃₂N₈O₄
• CAS Number: 126047-75-4
• Molecular Weight: 424.50
• UNSPSC Code: 12352209
• PubChem Substance ID: 24895231
• NACRES: NA.32
• MDL number: MFCD00237962

Properties

• Product Name: Gly-Pro-Arg-Pro amide, ≥97% (HPLC)
• Quality Segment: 200
• assay: ≥97% (HPLC)
• UniProt accession no.: P02751, P04937, P11276
• storage temp.: −20°C
• SMILES string: NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(N)=O
• InChI: 1S/C18H32N8O4/c19-10-14(27)25-8-3-6-13(25)16(29)24-11(4-1-7-23-18(21)22)17(30)26-9-2-5-12(26)15(20)28/h11-13H,1-10,19H2,(H2,20,28)(H,24,29)(H4,21,22,23)/t11-,12-,13-/m0/s1
• InChI key: SCCTZYGEMPQRCV-AVGNSLFASA-N
• Gene Information: human ... FN1(2335) ; mouse ... FN1(14268) ; rat ... FN1(25661)

Description

General description

Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the a chain of fibrin protein.[1]

Application

Gly-Pro-Arg-Pro amide has been used-

• as a constituent of buffer during fluid-phase and bound thrombin inhibition assays, to determine the activity of thrombin[2]
• for blocking fibrin polymerization and preventing fibrin clot formation in presence of α-thrombin, in blood obtained from mice[3]
• during preparation of human soluble fibrin, to block the polymerization of soluble fibrin[4]

Biochem/physiol Actions

Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid).[5]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)