G1044
Monoclonal Anti-Granzyme B antibody produced in mouse
clone GrB7, tissue culture supernatant
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Conjugate:
unconjugated
Clone:
GrB7, monoclonal
Application:
ICC, WB
Citations:
6
biological source
mouse
Quality Segment
conjugate
unconjugated
antibody form
tissue culture supernatant
antibody product type
primary antibodies
clone
GrB7, monoclonal
description
not suitable for immunocytochemistry (frozen sections)
mol wt
antigen 33 kDa
species reactivity
human
technique(s)
immunocytochemistry: 1:20 using pretreated tissues, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GZMB(3002)
Immunogen
recombinant human granzyme B.
Application
Monoclonal Anti-Granzyme B antibody is suitable for western blot and immunocytochemistry at a dilution of 1:20 using pretreated tissues.
Biochem/physiol Actions
Does not cross-react with granzyme A.
Granzyme B, neutral serine protease, is expressed in cytoplasmic granules of activated cytotoxic T lymphocytes and natural killer cells. It contains a leader sequence (cleaved by a signal peptidase) and two amino acid prodomains (cleaved by the lysosomal cysteine protease DPPI). It plays a major role in the caspase dependent apoptotic pathway by activating most of the caspases in vitro and in vivo. It cleaves the aspartic acid residues, to facilitate cell death by various pathways. It has been shown that granzyme B has capacity to facilitate cytochrome C release from the mitochondria in a caspase independent way.
Physical form
Supplied in serum-free culture medium containing 1% bovine serum albumin and 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Still not finding the right product?
Try our Product Selector Tool to narrow your options
Storage Class
12 - Non Combustible Liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.