As provided, every batch of this product released has been tested for solubility in methanol at concentrations up to about 10 mg/mL. It is also known to be soluble in organic solvents, e.g., ethanol (2 mg/mL), DMSO (5 mg/mL), and dimethyl formamide (10 mg/mL). The optimal solvent may vary depending on the specific application.
F4767
Filipin III from Streptomyces filipinensis
≥85% (HPLC)
Synonym(s):
Filimarisin
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About This Item
Empirical Formula (Hill Notation):
C35H58O11
CAS Number:
Molecular Weight:
654.83
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Pricing and availability is not currently available.
Quality Segment
assay
≥85% (HPLC)
form
powder
mp
163-180 °C
solubility
methanol: 9.80-10.20 mg/mL, clear, colorless to yellow
antibiotic activity spectrum
fungi, yeast
mode of action
cell membrane | interferes
storage temp.
−20°C
SMILES string
CCCCCC(O)C1C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)C(C)=C\C=C\C=C\C=C\C=C\C(O)C(C)OC1=O
InChI
1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14-
InChI key
IMQSIXYSKPIGPD-BWJOQPJXSA-N
Application
Filipin has been used in a double staining procedure as a probe for the detection of lipoproteins in polyacrylamide gel and immobilized on nitrocellulose membranes.
Filipin has been used in a double staining procedure as a probe for the detection of lipoproteins in polyacrylamide gel and immobilized on nitrocellulose membranes. It is also widely used to localize and quantitate unesterified cholesterol by virtue of a specific fluorescent complex.
Biochem/physiol Actions
Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action may be due to altering membrane permeability and associated functions by binding to membrane sterols. Filipin inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.
Other Notes
Filipin III is the major component of 8 isomeric components in filipin.
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This Item | |||
|---|---|---|---|
| assay ≥85% (HPLC) | assay ≥70% (UV) | assay ≥98% (HPLC) | assay ≥97% (HPLC) |
| Quality Level 300 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
| form powder | form powder | form crystalline powder | form powder |
| solubility methanol: 9.80-10.20 mg/mL, clear, colorless to yellow | solubility methanol: 9.80-10.20 mg/mL, clear to hazy, yellow to very deep greenish-yellow | solubility ethanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow | solubility methanol: 9.80-10.20 mg/mL, clear, yellow to very deep yellow |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| mp 163-180 °C | mp - | mp 175.4 °C | mp - |
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Good afternoon; I would be very grateful if you could clarify me which is the best solvent for filipin III (F4767) stock solution preparation. Product specification is different from product information (methanol; ethanol; DMSO..). Thank you in advance.
1 answer-
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