Key Documents

View All Documentation

F3503

5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt

Name: 5-Fluoro-2&#8242;-deoxyuridine 5&#8242;-monophosphate sodium salt
Brand: SIGMA

~85%, solid

Synonym(s):

FdUMP

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₉H₁₂FN₂O₈P

CAS Number:

103226-10-4

Molecular Weight:

326.17

UNSPSC Code:

41106305

PubChem Substance ID:

24894845

NACRES:

NA.51

MDL number:

MFCD00057409

Assay:

~85%

Form:

solid

Solubility:

water: 50 mg/mL, clear, colorless to faint yellow or tan

Storage temp.:

−20°C

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt, ~85%

assay

~85%

Quality Segment

200

form

solid

solubility

water: 50 mg/mL, clear, colorless to faint yellow or tan

storage temp.

−20°C

SMILES string

[Na].OC1CC(OC1COP(O)(O)=O)N2C=C(F)C(=O)NC2=O

InChI

1S/C9H12FN2O8P.Na.H/c10-4-2-12(9(15)11-8(4)14)7-1-5(13)6(20-7)3-19-21(16,17)18;;/h2,5-7,13H,1,3H2,(H,11,14,15)(H2,16,17,18);;

InChI key

DGEOOGBABXVZPJ-UHFFFAOYSA-N

Description

General description

5- 5-fluoro-2′-deoxyuridylate (FdUMP) is an intracellularly generated metabolite of 5-Fluorouracil (5-FU), a widely used reagent in molecular biology to study DNA synthesis and metabolism.

Application

It has been used:

as an anti-mitotic agent for culturing mouse primary cortical neurons.
as a component of feeding media in the culturing of mouse primary cortical neurons.
in studies on the activity and function of thymidylate synthase (TS).

Biochem/physiol Actions

5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt (FdUMP) is an DNA synthesis inhibitor. FdUMP along with RNA synthesis inhibitor 3′-C-ethinylcytidine induces cell death in cervical cancer cells at nanomolar concentrations.