F3004
Fetuin from fetal bovine serum
lyophilized powder
Synonym(s):
Fetuin from fetal calf serum
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About This Item
Recommended Products
biological source
bovine serum (fetal)
Quality Level
form
lyophilized powder
technique(s)
HPLC: suitable
MALDI-MS: suitable
impurities
~0.2% free N-acetylneuraminic acid
UniProt accession no.
storage temp.
2-8°C
Gene Information
bovine ... FETUB(504615)
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General description
Fetuin is an abundant glycosylated protein from fetal bovine serum and functions as a transport and storage protein. It is also called the α2-Heremans-Schmid glycoprotein (AHSG) and corresponds to a molecular weight of 64 kDa. It belongs to the statin family and is synthesized principally in the liver and partially in the kidneys, placenta and the tongue.
Application
Fetuin from fetal bovine serum has been used:
- as a standard glycoprotein in matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) and high-performance liquid chromatography-fluorescence detection analysis (HPLC-FLD)
- as a ligand in carbohydrate binding assay of pertussis toxin vaccine
- in the synthesis of fetuin-A conjugated gold nanoparticles (F-GNPs) for drug carrier studies
Biochem/physiol Actions
In humans, polymorphism in the fetuin gene is implicated in type 2 diabetes mellitus and modulates adipocyte functionality. Elevated level of fetuin is observed in obesity and nonalcoholic fatty liver diseases (NAFLD). Fetuin is a potential marker in clinical diagnosis of metabolic disorders.
Preparation Note
Further processing of F2379 by gel filtration.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Iqra Munir et al.
International journal of biological macromolecules, 101, 131-145 (2017-03-23)
Present study was conducted to establish the interaction of bovine fetuin-A to validate its binding modalities with doxorubicin (Dox). Fetuin-A was purified to highest purity and monodispersity. Green synthesis of fetuin-A conjugated gold nanoparticles (F-GNPs) has been performed giving typical
S R Fereidouni et al.
Veterinary microbiology, 135(3-4), 253-260 (2008-11-26)
Accurate identification of hemagglutinin (HA) and neuraminidase (NA) subtypes of influenza A viruses is an integral part of monitoring programs targeting avian influenza viruses (AIV). Use of highly sensitive molecular screening methods such as pan influenza-specific real-time RT-PCR (rRT-PCR) yields
Fetuin-A-Alpha2-Heremans-Schmid Glycoprotein: From Structure to a Novel Marker of Chronic Diseases Part 1. Fetuin-A as a Calcium Chaperone and Inflammatory Marker
Komsa-Penkova RS, et al.
Journal of Biomedical and Clinical Research, 10(2), 90-97 (2017)
Site-specific analysis of the O-glycosylation of bovine fetuin by electron-transfer dissociation mass spectrometry
Windwarder M and Altmann F
Journal of Proteomics, 108, 258-268 (2014)
A C Araujo et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 41(4), 571-578 (1993-04-01)
We investigated the localization of carbohydrate residues on the surface structures of microfilariae of Wuchereria bancrofti and Brugia malayi, using a panel of 10 different gold-labeled lectins and chitinase. The sheath, a structure that encloses the microfilariae, is not a
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