E5630

β-Estradiol 6-(O-carboxy­methyl)oxime: BSA

mitogen-activated protein kinase (MAPK) stimulator, lyophilized powder

• UNSPSC Code: 51111800
• NACRES: NA.77
• MDL number: MFCD03613560
• Form: lyophilized powder

Properties

• Product Name: β-Estradiol 6-(O-carboxy­methyl)oxime: BSA,
• sterility: non-sterile
• Quality Segment: 200
• form: lyophilized powder
• extent of labeling: ~30 mol steroid per mol BSA
• solubility: phosphate buffer: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow
• shipped in: ambient
• storage temp.: 2-8°C

Description

General description

β-Estradiol 6-(O-carboxy­methyl)oxime: BSA is an estradiol conjugate and is membrane-impermeable. BSA is linked to the estradiol at position 6 to form the β-estradiol 6-(O-carboxymethyl) oxime: BSA conjugate.

Application

β-Estradiol 6-(O-carboxy­methyl)oxime: BSA has been used:

• to test its effect on the N-methyl-D-aspartate receptor (NMDAR) currents in female dorsal root ganglion (DRG) neurons
• to coat microplates for the detection of plasma 17β-Estradiol levels using indirect enzyme-linked immunosorbent assay (ELISA)
• to test its effect on MutL homolog 1 in colorectal cancer lines

Biochem/physiol Actions

β-Estradiol 6-(O-carboxy­methyl)oxime: BSA mimics estrogen and favors amyloid precursor protein α (sAPPα) secretion in vitro studies with primary rat cortical neurons. It also stimulates mitogen-activated protein kinase (MAPK) activity in human umbilical vein endothelial cells

Safety Information

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332,H351
• pcodes: P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges