D5446

7,8-Dihydroxyflavone hydrate

≥98% (HPLC), Selective TrkB receptor agonist, solid

• Empirical Formula (Hill Notation): C₁₅H₁₀O₄ · xH₂O
• CAS Number: 38183-03-8
• Molecular Weight: 254.24 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 329798806
• UNSPSC Code: 12352200
• EC Number: 253-812-4
• MDL number: MFCD00006836
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Properties

• Product Name: 7,8-Dihydroxyflavone hydrate, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• solubility: DMSO: 24 mg/mL
• storage temp.: room temp
• SMILES string: Oc1ccc2C(=O)C=C(Oc2c1O)c3ccccc3
• InChI: 1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
• InChI key: COCYGNDCWFKTMF-UHFFFAOYSA-N

Description

Application

7,8-Dihydroxyflavone hydrate has been used as tropomyosin-receptor-kinase B (TrkB) agonist in mice and to inhibit TrkB for monitoring evoked excitatory postsynaptic currents (eEPSCs).

Biochem/physiol Actions

7,8-Dihydroxyflavone is a selective TrkB receptor agonist

7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease—without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.

7,8-Dihydroxyflavone (7,8-DHF) may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving, memory, vasorelaxation and hypertension. 7,8-DHF elicits protection in scopolamine induced Alzheimer-like pathologic dysfunction.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable