C8874

CGP-37157

≥98% (HPLC), SERCA antagonist , powder

• Synonym(s): 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
• Empirical Formula (Hill Notation): C₁₅H₁₁Cl₂NOS
• CAS Number: 75450-34-9
• Molecular Weight: 324.22
• UNSPSC Code: 12352200
• PubChem Substance ID: 329775189
• NACRES: NA.25
• MDL number: MFCD09055422
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: CGP-37157, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: DMSO: ≥20 mg/mL
• storage temp.: 2-8°C
• SMILES string: Clc1ccc2NC(=O)CSC(c3ccccc3Cl)c2c1
• InChI: 1S/C15H11Cl2NOS/c16-9-5-6-13-11(7-9)15(20-8-14(19)18-13)10-3-1-2-4-12(10)17/h1-7,15H,8H2,(H,18,19)
• InChI key: KQEPIRKXSUIUTH-UHFFFAOYSA-N

Description

General description

CGP-37157 is a benzothiazepine compound, which is derived from clonazepam. It functions as a sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA) antagonist and ryanodine receptor channels (RyR) agonist. CGP-37157 regulates intracellular signaling of calcium in smooth, cardiac and skeletal muscle cells and non-muscle systems.

Application

CGP-37157 has been used as a mitochondrial sodium-calcium exchanger (mNCX) inhibitor to study the role of normal mitochondrial calcium dynamics in sustaining dendritic spinogenesis.

Biochem/physiol Actions

Specific inhibitor of mitochondrial Na⁺/Ca²⁺ exchange as well as sarcoplasmic reticulum calcium-stimulated ATPase and possibly other calcium channels.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3