C5366
Chlorisondamine diiodide
≥98% (HPLC), nicotinic acetylcholine receptor antagonist, solid
Synonym(s):
4,5,6,7-Tetrachloro-2,3-dihydro-2-methyl-2-[2-(trimethylammonio)ethyl]-2H-isoindolium diiodide
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About This Item
Empirical Formula (Hill Notation):
C14H20Cl4I2N2
CAS Number:
Molecular Weight:
611.94
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Chlorisondamine diiodide, ≥98% (HPLC), white, solid
Quality Level
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
white
solubility
H2O: ≥2 mg/mL, DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
[I-].[I-].C[N+](C)(C)CC[N+]1(C)Cc2c(Cl)c(Cl)c(Cl)c(Cl)c2C1
InChI
1S/C14H20Cl4N2.2HI/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2
InChI key
FPNVAOZHQUJJJQ-UHFFFAOYSA-L
Application
Chlorisondamine diiodide has been used:
- as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
- as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
- as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress
Biochem/physiol Actions
Chlorisondamine diiodide mediates ganglionic and central blockade.
Irreversible, long-lasting nicotinic acetylcholine receptor antagonist.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Colin S Cunningham et al.
Pharmacology, biochemistry, and behavior, 179, 27-33 (2019-02-10)
Mecamylamine is a non-competitive nicotinic acetylcholine receptor (nAChR) antagonist that has been prescribed for hypertension and as an off-label smoking cessation aid. Here, we examined pharmacological mechanisms underlying the interoceptive effects (i.e., discriminative stimulus effects) of mecamylamine (5.6 mg/kg s.c.)
A Bai et al.
Scandinavian journal of immunology, 66(5), 538-545 (2007-10-24)
Inflammatory bowel diseases (IBD) are characterized by proinflammatory cytokines, tissue damage and loss of neuron in inflamed mucosa, which implies the cholinergic anti-inflammatory pathway may be destroyed during the process of inflammatory response. In the study, we identified the effect
T Mori et al.
Molecular pharmacology, 59(4), 732-743 (2001-03-22)
Inhalational general anesthetics have recently been shown to inhibit neuronal nicotinic acetylcholine (ACh) receptors (nnAChRs) expressed in Xenopus laevis oocytes and in molluscan neurons. However, drug actions on these systems are not necessarily the same as those seen on native
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C5366-10MG | 04061832081601 |
| C5366-50MG | 04061832081618 |