C4911

Chlorothiazide

synthetic (organic), ≥98% (HPLC), carbonic anhydrase inhibitor, powder

• Synonym(s): 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• Empirical Formula (Hill Notation): C₇H₆ClN₃O₄S₂
• CAS Number: 58-94-6
• Molecular Weight: 295.72
• NACRES: NA.77
• PubChem Substance ID: 24278150
• UNSPSC Code: 12352202
• EC Number: 200-404-9
• MDL number: MFCD00058576

Properties

• Product Name: Chlorothiazide, thiazide diuretic
• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• mp: >300 °C
• solubility: DMF: 50 mg/mL, clear, colorless to very faintly yellow
• storage temp.: 2-8°C
• SMILES string: O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O
• InChI: 1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
• InChI key: JBMKAUGHUNFTOL-UHFFFAOYSA-N
• Gene Information: human ... CA1(759), CA4(762), SLC12A3(6559)

Description

General description

Chlorothiazide (CTLD) is a thiazide-like diuretics and has antihypertensive effects.

Application

Chlorothiazide has been used as a reference standard in parallel artificial membrane permeability assay (PAMPA). It has also been used to test its effect on blocking pendrin activity.

One of the first in the thiazide class of diuretics.

Biochem/physiol Actions

Chlorothiazide (CTLD) shows structural resemblance with hydrochlorothiazide by having a sulfonamide group, but exhibits a long action duration. CTLD is an inhibitor of carbonic anhydrase and is more potent than hydrochlorothiazide.

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H317,H334
• pcodes: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves