A2251

Acetyl-β-methylcholine chloride

≥98% (TLC), powder

• Synonym(s): (2-Acetoxypropyl)trimethylammonium chloride, Methacholine chloride
• Linear Formula: CH₃COOCH(CH₃)CH₂N(Cl)(CH₃)₃
• CAS Number: 62-51-1
• Molecular Weight: 195.69
• UNSPSC Code: 12352211
• NACRES: NA.25
• PubChem Substance ID: 24277821
• EC Number: 200-537-2
• Beilstein/REAXYS Number: 4162373
• MDL number: MFCD00011817
• Assay: ≥98% (TLC)

Properties

• Quality Segment: 100
• assay: ≥98% (TLC)
• form: powder
• mp: 171-173 °C (lit.)
• solubility: H₂O: 50 mg/mL (solutions undergo rapid, pH-dependent decomposition at pH > 6.)
• storage temp.: −20°C
• SMILES string: [Cl-].CC(C[N+](C)(C)C)OC(C)=O
• InChI: 1S/C8H18NO2.ClH/c1-7(11-8(2)10)6-9(3,4)5;/h7H,6H2,1-5H3;1H/q+1;/p-1
• InChI key: JHPHVAVFUYTVCL-UHFFFAOYSA-M
• Gene Information: human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Description

Application

Acetyl-β-methylcholine (methacholine), an analog of acetylcholine, is use as a receptor agonist to study processes such as airway hyperresponsiveness associated with asthma.

Biochem/physiol Actions

Metabolically stable analog of acetylcholine; muscarinic agonist. Its ability to constrict airway smooth muscle is used to assess bronchial reactivity in the laboratory and clinically.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves