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https://www.sigmaaldrich.com/US/en/product/sigma/60615#product-documentation
60615
Kanamycin sulfate
mixture of Kanamycin A (main component) and Kanamycin B and C
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About This Item
Linear Formula:
C18H36-37N4-5O10-11 · H2SO4
CAS Number:
UNSPSC Code:
51281654
NACRES:
NA.85
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3874279
Pricing and availability is not currently available.
Quality Segment
form
powder or crystals
potency
≥750 units per mg (calculated with reference to dried substance)
ign. residue
≤0.5% (as SO4)
loss
≤1.5% loss on drying
color
white to off-white
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma
mode of action
protein synthesis | interferes
SMILES string
OS(O)(=O)=O.NC[C@H]1O[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
InChI
1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
InChI key
OOYGSFOGFJDDHP-KMCOLRRFSA-N
General description
Chemical structure: aminoglycoside
Application
Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium.†† Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 μg/mL.
Biochem/physiol Actions
Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding.
Mode of Resistance: Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.
Antimicrobial Spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.
Mode of Resistance: Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.
Antimicrobial Spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.
Packaging
5g, 25 g
Preparation Note
Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
Disclaimer
Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.
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This Item | |||
|---|---|---|---|
| mode of action protein synthesis | interferes | mode of action protein synthesis | interferes | mode of action protein synthesis | interferes | mode of action protein synthesis | interferes |
| antibiotic activity spectrum Gram-negative bacteria, mycobacteria, Gram-positive bacteria, mycoplasma | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycoplasma | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder or crystals | form powder | form powder or crystals | form powder |
| potency ≥750 units per mg (calculated with reference to dried substance) | potency ≥750 μg per mg (dry basis) | potency - | potency ≥750 μg per mg |
| color white to off-white | color white to off-white | color - | color - |
signalword
Danger
hcodes
Hazard Classifications
Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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