137252

BIS-TRIS hydrochloride

EMPROVE^® EVOLVE

• Synonym(s): BIS-TRIS hydrochloride, 2,2-Bis(hydroxymethyl)-2,2′,2″-nitrilotriethanol, 2-Bis(2-hydroxyethyl)amino-2-(hydroxymethyl)-1,3-propanediol, Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane
• Empirical Formula (Hill Notation): C₈H₁₉NO₅ · HCl
• CAS Number: 124763-51-5
• Molecular Weight: 245.70
• UNSPSC Code: 12161705
• MDL number: MFCD00171252

Properties

• biological source: synthetic
• Quality Segment: 400
• product line: EMPROVE^® EVOLVE
• assay: ≥99%
• form: powder
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, heavy metals, trace metals, residual solvents, tested
• pH: 5.8-7.2
• useful pH range: 5.8-7.2
• pKa: 6.5
• suitability: suitable for manufacturing use
• application(s): pharmaceutical (small molecule)
• foreign activity: Cytotoxicity, DNase, NICKase, RNase, and Protease; tested
• storage temp.: 2-30°C
• SMILES string: Cl.OCCN(CCO)C(CO)(CO)CO
• InChI: 1S/C8H19NO5.ClH/c10-3-1-9(2-4-11)8(5-12,6-13)7-14;/h10-14H,1-7H2;1H
• InChI key: VEYRVLHAMHQVTC-UHFFFAOYSA-N

Description

Application

Bis Tris HCl is a commonly used biological buffer for very broad usage in biological systems such as diagnostics, electrophoresis and protein based bioprocessing. The pKa of Bis Tris is 6.36, which makes it a good candidate for biological-based formulations.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable