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NIST1950

Metabolites in human plasma

NIST® SRM® 1950

Synonym(s):

Human Plasma Metabolites

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About This Item

UNSPSC Code:
41116107
NACRES:
NA.24
Pricing and availability is not currently available.

grade

certified reference material

Quality Level

100

form

liquid

packaging

pkg of 5 x 1 mL

manufacturer/tradename

NIST®

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable
mass spectrometry (MS): suitable

application(s)

clinical research

format

matrix material

Related Categories

General description

SRM 1950 is designed to represent “normal” human plasma.

It was developed in a collaboration between the National Institute of Standards and Technology (NIST) and the National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Analyses for value assignment were performed by NIST and the Centers for Disease Control and Prevention (CDC) (Atlanta, GA). All certified and reference values, with the exception of vitamin D-binding protein, are based on the agreement between the results from NIST methods and from the CDC, where available. The reference value for vitamin D-binding protein is based on the agreement between the results from a NIST method and the University of Washington method.

SRM 1950 _SDS

SRM 1950_CERT

Application

This Standard Reference Material (SRM) is intended primarily for the validation of methods for determining metabolites such as fatty acids, electrolytes, vitamins, hormones, and amino acids in human plasma and similar materials. This SRM can also be used for comparison of measurement technologies used in metabolomic studies and for quality assurance when assigning values to in-house reference materials.

The standard has been used:

  • to determine the accuracy of vitamin D in human serum by liquid chromatography-tandem mass spectrometry (LC-MS/MS)[1]
  • to determine the unbound free fatty acid profile of human plasma[2]
  • to determine the C24 bile acids in human serum and urine samples by liquid chromatography-mass spectrometry (LC-MS) method[3]

Features and Benefits

  • A unit of SRM 1950 consists of five vials, each containing approximately 1.0 mL of plasma
  • The associated uncertainties are expressed at the 95 %level of confidence
  • Information on product description, disposal, and transportation is available in the accompanying MSDS
  • The enclosed NIST certificate contains details on the expiry date, warning to users, instructions for right storage and use, preparation, and analysis of the RM

Legal Information

NIST is a registered trademark of National Institute of Standards and Technology
SRM is a registered trademark of National Institute of Standards and Technology

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

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Certificates of Analysis (COA)

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Quantification of vitamin D and 25-hydroxyvitamin D in soft tissues by liquid chromatography-tandem mass spectrometry
Lipkie TE, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 932, 6-11 (2013)
Unbound free fatty acid profiles in human plasma and the unexpected absence of unbound palmitoleate
Huber AH and Kleinfeld AM
Journal of Lipid Research, 58(3), 578-585 (2017)
Analysis of human C24 bile acids metabolome in serum and urine based on enzyme digestion of conjugated bile acids and LC-MS determination of unconjugated bile acids
Zhu P, et al.
Analytical and Bioanalytical Chemistry, 410(21), 5287-5300 (2018)

Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. What are the compounds and their level present in the NIST1950 (Metabolites in human plasma)

    1 answer

    1. The composition information for this product can be found on NIST certification. Please review the certificate of analysis for this standard: https://www-s.nist.gov/srmors/certificates/1950.pdf.

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