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Sodium Orthovanadate

Name: Sodium Orthovanadate
Brand: MM

A broad spectrum potent inhibitor of protein tyrosine phosphatases.

Synonym(s):

Sodium Orthovanadate, PTP Inhibitor X

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About This Item

Empirical Formula (Hill Notation):

Na₃O₄V

CAS Number:

13721-39-6

Molecular Weight:

183.91

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00003511

Form:

solid

Storage condition:

OK to freeze

Pricing and availability is not currently available.

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Properties

Quality Segment

100

description

RTECS - YW1120000

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white to off-white

input

general use sample(s)

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

10-30°C

SMILES string

[V](=O)([O-])([O-])[O-].[Na+].[Na+].[Na+]

InChI

1S/3Na.4O.V/q3*+1;;3*-1;

InChI key

IHIXIJGXTJIKRB-UHFFFAOYSA-N

Description

General description

A broad spectrum potent inhibitor of protein tyrosine phosphatases. Also known to inhibit Na⁺/K⁺ ATPase, acid and alkaline phosphatases, phosphofructokinase, and adenylate kinase. Most recently shown to inhibit ATPase activity of the reconstituted binding protein-dependent ATP-Binding Cassette (ABC) transporter for maltose (MalFGK₂) of Salmonella typhimurium in the micromolar range. Can be converted to pervanadate by hydrogen peroxide.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Na⁺,K⁺-ATPase, acid , alkaline phosphatases, phosphofructokinase, and adenylate kinase

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Huyer, G., et al. 1997. J. Biol. Chem. 272, 843.
Hunke, S., et al. 1995. Biochem. Biophys. Res. Commun.216, 589.
Levchuck, S.G., et al. 1994. Pediatric Res.37, 382A.
Fohr, K.J., et al. 1989. Biochem. J.262, 83.
Swarup, G., et al. 1982. Biochem. Biophys. Res. Commun.107, 1104.
Seargeant, L.E. and Stinson, R.A. 1979. Biochem. J.181, 247.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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This Item	450243	S6508	203694
Sigma-Aldrich 567540 Sodium Orthovanadate	Sigma-Aldrich 450243 Sodium orthovanadate	Sigma-Aldrich S6508 Sodium orthovanadate	Sigma-Aldrich 203694 bpV(bipy)
description A broad spectrum potent inhibitor of protein tyrosine phosphatases.	description 99.98% trace metals basis	description ≥90% (titration)	description A potent inhibitor of phosphotyrosine phosphatase (K_i = 100 nM for insulin receptor dephosphorylation).
form solid	form solid	form crystalline powder	form solid
manufacturer/tradename Calbiochem^®	manufacturer/tradename -	manufacturer/tradename -	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 100
storage temp. 10-30°C	storage temp. -	storage temp. -	storage temp. −20°C
solubility water: 10 mg/mL	solubility -	solubility H₂O: soluble	solubility water: 5 mg/mL
storage condition OK to freeze	storage condition -	storage condition -	storage condition OK to freeze, protect from light

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Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H302 + H312 + H332,H315,H319

Precautionary Statements

P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

13 - Non Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)