Key Documents

View All Documentation

Metastin (45-54)

Name: Metastin (45-54)
Brand: MM

A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors).

Synonym(s):

Metastin (45-54), KiSS-1 (112-121), Kisspeptin-10, H-YNWNSFGLRF-NH₂

Select a Size

Change View

Size/SKU	Availability	Price

About This Item

Empirical Formula (Hill Notation):

C₆₃H₈₃N₁₇O₁₄

Molecular Weight:

1302.44

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥97% (HPLC)

Form:

lyophilized solid

Storage condition:

OK to freeze, desiccated (hygroscopic)

Pricing and availability is not currently available.

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Quality Segment

100

assay

≥97% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Description

General description

A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors). Induces an increase in intracellular Ca²⁺ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (K_i = 42 pM) compared to Metastin (Cat. No. 445885).

Biochem/physiol Actions

Cell permeable: no

Primary Target
AXOR12 and hOT7T175

Product does not compete with ATP.

Reversible: no

Target K_i: 42 pM for AXOR12 and hOT7T175

Packaging

Packaged under inert gas

Other Notes

H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂

Kotani, M., et al. 2001. J. Biol. Chem.276, 34631.
Ohtaki, T., et al. 2001. Nature411, 613.
Muir, A.I., et al. 2001. J. Biol. Chem.276, 28969.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	M2816	444258	219381
Sigma-Aldrich 445888 Metastin (45-54)	Sigma-Aldrich M2816 Metastin (45-54) amide, human	Sigma-Aldrich 444258 MMP-14 Substrate I, Fluorogenic	Sigma-Aldrich 219381 Cathepsin K Inhibitor III
description A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors).	description ≥95%	description A specific fluorescence resonance energy transfer (FRET) peptide substrate for the detection of MMP activity.	description The Cathepsin K Inhibitor III controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
assay ≥97% (HPLC)	assay ≥95%	assay ≥97% (HPLC)	assay ≥97% (HPLC)
form lyophilized solid	form -	form lyophilized solid	form lyophilized solid
manufacturer/tradename Calbiochem^®	manufacturer/tradename -	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
storage condition OK to freeze, desiccated (hygroscopic)	storage condition -	storage condition protect from light, OK to freeze	storage condition desiccated (hygroscopic), OK to freeze

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.