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444218

Sigma-Aldrich

MMP-3 Inhibitor I

The MMP-3 Inhibitor I controls the biological activity of MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

MMP-3 Inhibitor I, Ac-RCGVPD-NH₂, Stromelysin-1 Inhibitor

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About This Item

Empirical Formula (Hill Notation):
C27H46N10O9S
Molecular Weight:
686.78
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

Inhibits matrix metalloproteinase-3 (stromelysin) (IC50 = 5 µM). The inhibitor is based on a segment from the conserved region of the NH2-terminal propeptide domain.
Inhibits the matrix metalloproteinase MMP-3 (IC50 = 5 µM).

Biochem/physiol Actions

Cell permeable: no
Primary Target
MMP-3
Product does not compete with ATP.
Reversible: no
Target IC50: 5 µM against MMP-3

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Arg-Cys-Gly-Val-Pro-Asp-NH₂

Physical form

Supplied as a trifluroacetate salt.

Reconstitution

Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for 1-2 weeks at -20°C.

Other Notes

Fotouhi, N., et al. 1994. J. Biol. Chem. 269, 30227.
Hanglow, A.C., et al. 1993. Agents Actions 39, C148.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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