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309795

DIDS disodium salt

≥85% (HPLC), solid, anion transport inhibitor, Calbiochem®

Synonym(s):

DIDS, Disodium Salt, 4,4ʹ-Diisothiocyanostilbene-2,2ʹ-disulfonic Acid, 2Na

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About This Item

Empirical Formula (Hill Notation):
C16H8N2O6S4 · 2Na
CAS Number:
Molecular Weight:
498.48
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥85% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated, protect from light
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Product Name

DIDS, Disodium Salt, Binds covalently and irreversibly to the outer surface of human erythrocyte membranes.

Quality Segment

assay

≥85% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated, protect from light

color

yellow

solubility

water: 0.5%

shipped in

ambient

storage temp.

−20°C

SMILES string

[S](=O)(=O)(O)c1c(ccc(c1)N=C=S)\C=C\c2c(cc(cc2)N=C=S)[S](=O)(=O)O

InChI

1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+

InChI key

YSCNMFDFYJUPEF-OWOJBTEDSA-N

General description

Binds covalently and irreversibly to the outer surface of human erythrocyte membrane proteins. Inhibits ATP transport into the endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl- uptake (IC50 = 150 nM) in neuroblastoma cells. Has antiulcerous activity.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Cl- uptake
Product does not compete with ATP.
Reversible: no
Target IC50: 150 nM inhibiting Cl- uptake in neuroblastoma cells

Other Notes

Bettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol.15, 207.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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525276506600217386
description

Binds covalently and irreversibly to the outer surface of human erythrocyte membranes.

description

Inhibits some metalloendopeptidases.

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A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used.

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Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2⁻/NO3⁻ with a rate constant of 1 x 10⁴ M⁻¹sec⁻¹.

form

solid

form

lyophilized solid

form

solid

form

solid

assay

≥85% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥97% (TLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

OK to freeze, desiccated, protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

desiccated (hygroscopic), OK to freeze

storage condition

OK to freeze, protect from light, desiccated (hygroscopic)


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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