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Apolipoprotein B, Human Plasma, Low-Density Lipoprotein

Name: Apolipoprotein B, Human Plasma, Low-Density Lipoprotein
Brand: MM

Native apolipoprotein B from human plasma. It is a dominant protein constituent of LDL and VLDL. Acts as a ligand for LDL receptor, directing clearance of LDL from plasma to the liver.

Synonym(s):

Apo B, Apo B-100

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About This Item

NACRES:

NA.25

UNSPSC Code:

12352202

Form:

solid

Assay:

≥95% (SDS-PAGE)

Pricing and availability is not currently available.

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Properties

Quality Segment

100

assay

≥95% (SDS-PAGE)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

shipped in

ambient

storage temp.

−20°C

Description

General description

Native apolipoprotein B from human plasma. Produced by the liver, and is a dominant protein constituent of LDL that is also present in VLDL. Ligand for LDL receptor, directing clearance of LDL from plasma to the liver. Functions as a cofactor in enzymatic reactions. Mean serum concentration: 950 µg/ml. Higher levels are reported in familial hyperlipidemia, obesity, and diabetes.

Physical form

Lyophilized from 50 mM Na₂CO₃, 50 mM NaCl, 10 mM sodium deoxycholate, pH 10.0.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Please refer to the label for lot-specific reconstitution volume.

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Other Notes

Jiang, X.C., et al. 2001. Nat. Med.1, 847.
Zhou, M., et al. 1995. J. Biol. Chem.270, 25220.
Sivaram, P., et al. 1993. J. Biol. Chem.269, 9409.
Sato, R., et al. 1990. J. Biol. Chem. 265, 11880.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Toxicity: Standard Handling (A)

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This Item	ALP30	178455	178468
Sigma-Aldrich 178456 Apolipoprotein B, Human Plasma, Low-Density Lipoprotein	Sigma-Aldrich ALP30 Apolipoprotein B, human	Sigma-Aldrich 178455 Apolipoprotein A-II, Human Plasma, High-Density Lipoprotein	Sigma-Aldrich 178468 Apolipoprotein E, Human Plasma, Very Low-Density Lipoprotein
description Native apolipoprotein B from human plasma. It is a dominant protein constituent of LDL and VLDL. Acts as a ligand for LDL receptor, directing clearance of LDL from plasma to the liver.	description -	description Native apolipoprotein A-II from human plasma. The second most abundant protein of HDL. Binds to phospholipids during lipoprotein metabolism. Displaces LCAT bound to lipoprotein.	description Native apolipoprotein E from human plasma. A major component of VLDL and IDL. Serves as a major cholesterol carrier. Essential for the normal catabolism of triglyceride-rich lipoprotein constituents.
assay ≥95% (SDS-PAGE)	assay >95% (SDS-PAGE)	assay ≥95% (SDS-PAGE)	assay ≥95% (SDS-PAGE)
form solid	form solid	form liquid	form liquid
storage condition OK to freeze	storage condition -	storage condition avoid repeated freeze/thaw cycles, OK to freeze	storage condition OK to freeze, avoid repeated freeze/thaw cycles
storage temp. −20°C	storage temp. -10 to -25°C	storage temp. −20°C	storage temp. −20°C
shipped in ambient	shipped in dry ice	shipped in wet ice	shipped in wet ice
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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