Xenobiotica; the fate of foreign compounds in biological systems, 17(7), 815-821 (1987-07-01)
The patterns of metabolic conjugation of the isomeric 1- and 2-naphthylacetic acids have been compared in guinea pig, mouse, hamster and gerbil. Equimolar doses of [carboxy-14C]1- and 2-naphthylacetic acids were given to these species by i.p. injection, their urine collected
Rapid communications in mass spectrometry : RCM, 17(12), 1339-1343 (2003-06-18)
The feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP-DIOS-MS) for drug analysis was investigated. It was observed that only compounds with relative high proton affinity are efficiently ionized under AP-DIOS conditions. The limits of detection (LODs) achieved in
Archives of biochemistry and biophysics, 388(2), 231-236 (2001-05-23)
A simple method useful for the joint evaluation of substrate partitioning and kinetic parameters for reactions catalyzed by enzymes entrapped in reverse micelles is proposed. The method is applied to the hydrolysis of 2-naphthyl acetate (2-NA) catalyzed by lipase in
The current status of attempts to predict species differences in drug metabolism.
J Caldwell
Drug metabolism reviews, 12(2), 221-237 (1981-01-01)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
