44570

Dowtherm^® A

eutectic mixture of 26.5% diphenyl + 73.5% diphenyl oxide

• Synonym(s): Diphyl
• NACRES: NA.22
• PubChem Substance ID: 57650233
• UNSPSC Code: 12352100
• MDL number: MFCD00148859

Properties

• Quality Segment: 100
• refractive index: n20/D 1.590
• functional group: phenoxy, phenyl
• SMILES string: c1ccc(cc1)-c2ccccc2.O(c3ccccc3)c4ccccc4
• InChI: 1S/C12H10O.C12H10/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12;1-3-7-11(8-4-1)12-9-5-2-6-10-12/h1-10H;1-10H
• InChI key: MHCVCKDNQYMGEX-UHFFFAOYSA-N

Description

General description

Dowtherm^® A is a thermally stable organic heat transfer fluid composed of a eutectic mixture of highly stable compounds, biphenyl, and diphenyl oxide. Dowtherm^® A is suitable for high-temperature heat transfer applications up to 400 °C. This fluid can be used in both liquid and vapor phase systems.

Application

Dowtherm^® A can be used as a high boiling solvent in cyclization reactions. For example, it is used to synthesize:      

• 1-Hydroxy-5-methoxy-1,2-dihydrobenzo[f][2,7]naphthyridines from 2-chloro-3-formyl quinolines.     
• Isoindolinone derivatives via intramolecular Diels–Alder cycloaddition reactions of substituted pyridazines.
• Phosphorylated azaheterocycles from 2-diethoxyphosphoryl-3-methoxyacrylate via intramolecular cyclizations under thermal conditions.

Legal Information

DOWTHERM is a registered trademark of The Dow Chemical Company or an affiliated company of Dow

Safety Information

• target_organs: Respiratory system
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type ABEK (EN14387) respirator filter
• pictograms: GHS08,GHS07,GHS09
• signalword: Danger
• hcodes: H315,H319,H335,H360Fd,H410
• pcodes: P202 - P261 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects