177466
4-Methylcyclohexylamine, mixture of cis and trans
97%
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About This Item
Linear Formula:
CH3C6H10NH2
CAS Number:
Molecular Weight:
113.20
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Assay
97%
form
liquid
refractive index
n20/D 1.4531 (lit.)
bp
151-154 °C (lit.)
density
0.855 g/mL at 25 °C (lit.)
SMILES string
CC1CCC(N)CC1
InChI
1S/C7H15N/c1-6-2-4-7(8)5-3-6/h6-7H,2-5,8H2,1H3
InChI key
KSMVBYPXNKCPAJ-UHFFFAOYSA-N
General description
Trans-4-methylcyclohexylamine is a spermidine synthase inhibitor.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Flam. Liq. 3 - Skin Corr. 1B
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
80.6 °F - closed cup
Flash Point(C)
27 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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TachaZi Plym Forshell et al.
Cancer prevention research (Philadelphia, Pa.), 3(2), 140-147 (2010-01-28)
The oncogenic transcription factor c-Myc (Myc) is frequently overexpressed in human cancers. Myc is known to induce or repress a large set of genes involved in cell growth and proliferation, explaining the selection for mutations in cancer that deregulate Myc
Masatake Sano et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 845(1), 80-83 (2006-08-26)
An assay for spermidine synthase (SPDS) activity in rat liver has been developed using micellar electrokinetic chromatography (MEKC) with laser-induced fluorescence (LIF) detection to enable the discovery of SPDS inhibitors. The assay was established by estimating the amount of spermidine
Masaki Kobayashi et al.
Biological & pharmaceutical bulletin, 28(4), 569-573 (2005-04-02)
In rat tissues, a decrease in spermidine, accompanied by an increase in spermine was induced by the oral administration (once daily for either 1 week or 1 month) of trans-4-methylcyclohexylamine (4MCHA), a spermidine synthase inhibitor. This is similar to the
Ikumi Ishii et al.
Amino acids, 42(2-3), 619-626 (2011-08-03)
Polyamines spermidine and spermine are known to be required for mammalian cell proliferation and for embryonic development. Alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC) a limiting enzyme of polyamine biosynthesis, depleted the cellular polyamines and prevented triglyceride accumulation and
Keijiro Samejima et al.
Biological & pharmaceutical bulletin, 30(10), 1943-1946 (2007-10-06)
A sensitive method for the determination of polyamines in mammalian cells was described using electrospray ionization and time-of-flight mass spectrometer. This method was 50-fold more sensitive than the previous method using ionspray ionization and quadrupole mass spectrometer. The method employed
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