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Key Documents

SRP6319

Sigma-Aldrich

Kininogen,LMW from human plasma

≥95% (SDS-PAGE)

Synonym(s):

Alpha-2-thiol proteinase inhibitor, BDK, Fitzgerald factor, High molecular weight Kininogen, KNG, Kininogen-1 heavy chain, Low molecular weight growth-promoting, Williams-Fitzgerald-Flaujeac factor

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100 μG
3.595,00 R$

3.595,00 R$


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Estimated to ship on09 March 2025



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100 μG
3.595,00 R$

About This Item

UNSPSC Code:
12352200

3.595,00 R$


Availability

Estimated to ship on09 March 2025


biological source

human plasma

Assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

65 kDa

packaging

pkg of 100 μg

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... KNG1(3827)

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HPA011952HPA030568SAB1410503
Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

shipped in

dry ice

shipped in

wet ice

shipped in

wet ice

shipped in

dry ice

Gene Information

human ... STBD1(8987)

Gene Information

human ... STBD1(8987)

Gene Information

human ... SRBD1(55133)

Gene Information

human ... STAP1(26228)

General description

KNG1 (kininogen 1) gene is localized to human chromosome 3, and codes for both high and low molecular weight kininogen.[1][2] The high molecular weight kininogen (HK) is a 120kDa single chain glycoprotein.[3]
LMW Kininogen is involved in blood pressure regulation since it is an endogenous protein substrate for tissue kallikrein. Proteolytic cleavage by kallikrein releases vasoactive bradykinin from LMW kininogen. In addition, LMW kininogen, like HMW kininogen, is a major extracellular cysteine protease inhibitor.

Biochem/physiol Actions

KNG1 (kininogen 1) exists in low and high molecular weight forms which are precursors for bradykinin and kallidin (Lys-Bradykinin), respectively.[2] The high molecular weight kininogen (HK) functions as a cofactor for the stimulation of surface-bound Hageman factor (Factor XII) by kallikrein. HK is subsequently required for the activation of prekallikrein and Factor XI by the activated Hageman factor. These steps are essential for the initiation of coagulation, fibrinolysis, and the production of vasoactive peptides.[1][3] Ile581Thr polymorphism in KNG1 gene is linked with increased susceptibility to venous thrombosis.[4]

Physical form

Lyophilized from 10 mM Na acetate, pH 5.5 with 200 mM NaCI .

Reconstitution

In water or aqueous buffer

Pictograms

Health hazardExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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The shape of high molecular weight kininogen. Organization into structural domains, changes with activation, and interactions with prekallikrein, as determined by electron microscopy.
Weisel JW, et al.
The Journal of Biological Chemistry, 269(13), 10100-10106 (1994)
Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.
Houlihan LM, et al.
American Journal of Human Genetics, 86(4), 626-631 (2010)
Genome-wide meta-analyses of plasma renin activity and concentration reveal association with the kininogen 1 and prekallikrein genes.
Lieb W, et al.
Circulation. Cardiovascular Genetics, 8(1), 131-140 (2015)
KNG1 Ile581Thr and susceptibility to venous thrombosis.
Morange PE, et al.
Blood, 117(13), 3692-3694 (2011)

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