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SML3323

Sigma-Aldrich

MS9715

≥98% (HPLC)

Synonym(s):

(2S,4R)-1-((S)-2-(9-(4-((4-(5-(7-fluoroquinolin-4-yl)-1-methyl-1H-imidazol-4-yl)-3,5-dimethylbenzyl)amino)butanamido)nonanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C58H74FN9O5S
Molecular Weight:
1028.33
UNSPSC Code:
12352200
NACRES:
NA.32

Quality Level

100

Assay

≥98% (HPLC)

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=C(C(C)=CC(CNCCCC(NCCCCCCCCC(N[C@H](C(N2[C@@H](C[C@H](C2)O)C(N[C@H](C3=CC=C(C=C3)C4=C(N=CS4)C)C)=O)=O)C(C)(C)C)=O)=O)=C1)C5=C(N(C=N5)C)C6=CC=NC7=C6C=CC(F)=C7

Biochem/physiol Actions

MS9715 is a potent and highly selective degrader (PROTAC) of NSD3 (Nuclear receptor binding SET domain protein 3) that effectively depletes NSD3 and the associated cMyc oncogenic node. MS9715 comprised of NSD3 antagonist BI-9321 linked to an E3 ligase VHL ligand. It potently inhibits growth of NSD3-dependent hematological cancer cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

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