SML0821

UCD38B hydrochloride

≥98% (HPLC)

• Synonym(s): 5’-Benzylglycinyl-amiloride, N-[6-Amino-5-[[(aminoiminomethyl)amino]carbonyl]-3-chloro-2-pyrazinyl]-glycine phenylmethyl ester hydrochloride
• Empirical Formula (Hill Notation): C₁₅H₁₆ClN₇O₃ · xHCl
• CAS Number: 1115177-19-9
• Molecular Weight: 377.79 (free base basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825604
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 15 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: NC(NC(C(N=C1Cl)=C(N)N=C1CNC(OCC2=CC=CC=C2)=O)=O)=N.[H]Cl
• InChI: 1S/C15H16ClN7O3.ClH/c16-11-9(21-12(17)10(22-11)13(24)23-14(18)19)6-20-15(25)26-7-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H2,17,21)(H,20,25)(H4,18,19,23,24);1H
• InChI key: SFHYWDNJBRFZKW-UHFFFAOYSA-N

Description

Biochem/physiol Actions

UCD38B is a cell permeable inhibitor of intracellular uPA (urokinase plasminogen activator) that is cytotoxic to proliferating and non-proliferating glioma cell lines. UCD38B induces caspase-independent necrosis in U87 glioma MDA231 breast cancer cells. It appears that the necrotic pathway is mediated by AIF (apoptotic inducible factor).

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable