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SML0350

Sigma-Aldrich

AZD-7762 hydrochloride

≥98% (HPLC)

Synonym(s):

5-(3-Fluorophenyl)-3-ureidothiophene-2-carboxylic acid N-[(S)-piperidin-3-yl]amide hydrochloride, AZD 7762 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H19FN4O2S · HCl
CAS Number:
1246094-78-9
Molecular Weight:
398.88
MDL number:
MFCD12546135
UNSPSC Code:
12352200
PubChem Substance ID:
329825353
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to light brown

solubility

DMSO: 15 mg/mL, clear

storage temp.

−20°C

SMILES string

Cl.NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)-c3cccc(F)c3

InChI

1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1

InChI key

WFZBLOIXZRZEDG-YDALLXLXSA-N

Application

AZD-7762 hydrochloride has been used:
  • as a checkpoint kinase 1 and 2 (CHK1/2) inhibitor to study its effect on the efficiency of non-homologous end-joining (NHEJ) repair in breast cancer cell lines
  • as a CHK1 inhibitor to serve as a positive control for replication stress in the assessment of fork restart events
  • as a CHK1/2 inhibitor to study its effects on DNA lesions during mice zygote development

Biochem/physiol Actions

AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2 that enhanced cytotoxicity DNA-damaging agents.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H318

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Peter Tonzi et al.
eLife, 7 (2018-11-14)
DNA replication stress is often defined by the slowing or stalling of replication fork progression leading to local or global DNA synthesis inhibition. Failure to resolve replication stress in a timely manner contribute toward cell cycle defects, genome instability and
Sabrina Ladstätter et al.
Cell, 167(7), 1774-1787 (2016-12-06)
Sexual reproduction culminates in a totipotent zygote with the potential to produce a whole organism. Sperm chromatin reorganization and epigenetic reprogramming that alter DNA and histone modifications generate a totipotent embryo. Active DNA demethylation of the paternal genome has been
Andrea M Pesch et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 26(24), 6568-6580 (2020-09-25)
Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have improved progression-free survival for metastatic, estrogen receptor-positive (ER+) breast cancers, but their role in the nonmetastatic setting remains unclear. We sought to understand the effects of CDK4/6 inhibition (CDK4/6i) and radiotherapy in multiple preclinical

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