Detects ~190 kDa. No cross-reactivity against Shank1 or Shank2.
Immunogen
Synthetic peptide amino acids 840-857 of rat Shank3, Accession Number Q9JLU4
Features and Benefits
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Physical form
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(23), 5289-5301 (2018-05-08)
Mutations or altered protein levels of SHANK3 are implicated in neurodevelopmental disorders such as Phelan-McDermid syndrome, autism spectrum disorders, and schizophrenia (Guilmatre et al., 2014). Loss of SHANK3 in mouse models results in decreased synapse density and reduction in the
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