SAB4200268

Anti-Tensin 2 (C-terminal) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-C1TEN, Anti-TENC1, Anti-TNS2
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• mol wt: antigen ~160 kDa
• species reactivity: human
• enhanced validation: recombinant expression; Learn more about Antibody Enhanced Validation
• concentration: ~1.5 mg/mL
• technique(s): western blot: 1.5-3.0 μg/mL using HEK-293T cells over expressing human tensin 2.
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... TENC1(23371)

Description

General description

Tensin 2 belongs to the Tensin family. It shares extensive homology with tensin1 at its N- and C-terminals, including the actin-binding domain, the Src Homology 2 (SH2) and c domains. Tensin 2 mRNA is highly expressed in heart, kidney, skeletal muscle and liver.

Immunogen

synthetic peptide corresponding to a sequence located near the C-terminus human tensin 2 (GeneID: 23371), conjugated to KLH. The corresponding sequence is identical in human tensin 2 isoforms 2 and 3, and highly conserved (single amino acid substitution) in mouse tensin 2.

Application

Anti-Tensin 2 (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.

Biochem/physiol Actions

Tensin 2 interacts with several binding partners through its Src Homology 2 (SH2)-phosphotyrosine binding (PTB) domains, including Axl receptor tyrosine kinase (RTK), caveolin-1 and with the tumor suppressor gene deleted in liver cancer 1 (DLC1) to regulate DLC1 tumor suppressor activity. Tensin 2 also inhibits Akt signaling and cell survival. It reduces intracellular PtdIns(3,4,5)P₃ levels at the plasma membrane. It modulates cytoskeletal dynamics and impacts phosphoinositide-Akt signaling through its PTPase domain. Tensin 2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma (HCC).

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable