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RAB0780

Sigma-Aldrich

Mouse Tyro3 / Tyrosine-protein Kinase Receptor TYRO3 ELISA Kit

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

mouse

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type cell culture supernatant(s)
sample type serum
sample type plasma

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.4 ng/mL
standard curve range: 0.416-100 ng/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Tyro3(22174)

General description

The antibody pair provided in this kit recognizes mouse Tyro3.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Tyrosine-protein kinase receptor (TYRO3) is a transmembrane tyrosine kinase receptor. It plays a significant role in the brain development during embryogenesis. It plays an important role in apoptotic cell clearance. In hepatocellular carcinoma, it is associated with tumor growth, aggressiveness and liver dysfunction. Mutations in the TYRO3 gene intronic regions are linked with asthma. TYRO3 is also a suppressor of type 2 immunity. As part of the TAM (TYRO3, AXL and MER receptors) family, it is activated by PROS1 (protein S) and GAS6 (growth arrest-specific gene 6). Changes in the expression of TYRO3 are linked with the proliferation and survival of cancer cells. Absence of TYRO3 in mice results in neurological disorders.

Kit Components Also Available Separately

Product No.
Description
SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The Gas6/TAM System and Multiple Sclerosis.
Bellan M, et al.
International Journal of Molecular Sciences, 17 (2016)
Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation.
Tsou WI
The Journal of Biological Chemistry, 289, 25750-25763 (2014)
Increased soluble phagocytic receptors sMer, sTyro3 and sAxl and reduced phagocytosis in juvenile-onset systemic lupus erythematosus.
Ballantine L, et al.
Pediatric Rheumatology Online Journal (2015)
Overexpression of Tyro3 and its implications on hepatocellular carcinoma progression.
Duan Y
International Journal of Oncology, 48, 358-366 (2016)
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity.
Chan PY
Science, 352, 99-103 (2016)

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