B-lymphocyte activating factor (BAFF/TNFSF13B) is a cytokine that belongs to the TNF (tumor necrosis factor) superfamily. BAFF is located on human chromosome 13q33.
Immunogen
a peptide corresponding to amino acids near the carboxy-terminus of human BAFF.
Biochem/physiol Actions
B cell activating factor (BAFF) participates in B cell and T cell mediated immunity. It plays a key role in the survival and differentiation of B cells. Mutations in BAFF regulates the levels of antibody. BAFF also participates in enhancing the responses of IL-6 (interlukin-6) and TNF-α (tumor necrosis factor alpha), that helps hepatocytes in the production of acute-phase protein.
Linkage
The action of this antibody can be blocked using blocking peptide SBP2221.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Disclaimer
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Polymorphism in the 5′ regulatory region of the B-lymphocyte activating factor gene is associated with the Ro/La autoantibody response and serum BAFF levels in primary Sjogren's syndrome.
Nossent JC, et al.
Rheumatology (Basel), 47(9), 1311-1316 (2008)
Association of genetic variation in B-cell activating factor with chronic hepatitis B virus infection.
Han Q, et al.
Immunology Letters, 188, 53-58 (2017)
B cell-activating factor regulates the survival of B lymphocytes infected with human cytomegalovirus.
Xu H, et al.
Immunology Letters, 187, 1-6 (2017)
Association between total immunoglobulin E and antibody responses to naturally acquired Ascaris lumbricoides infection and polymorphisms of immune system?related LIG4, TNFSF13B and IRS2 genes.
Acevedo N, et al.
Clinical and Experimental Immunology, 157(2), 282-290 (2009)
Increased levels of BAFF in patients with systemic lupus erythematosus are associated with acute-phase reactants, independent of BAFF genetics: a case?control study.
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