All Photos(2)
About This Item
Empirical Formula (Hill Notation):
C8H8O4
CAS Number:
Molecular Weight:
168.15
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
form
solid
SMILES string
O=C1OC(=O)C2C3CCC(O3)C12
InChI
1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2
InChI key
JAABVEXCGCXWRR-UHFFFAOYSA-N
Gene Information
human ... PPP2R5A(5525)
General description
Norcantharidin (NCTD) is a demethylated derivative of cantharidin (CTD).
Application
Norcantharidin has been used in primary cell culture and treatment. It has also been used to treat mice inoculated with Huh7 cells subcutaneously.
Biochem/physiol Actions
Norcantharidin is a potential antitumor agent. Norcantharidin helps to block SK-N-SH neuroblastoma cell growth by stimulating autophagy and apoptosis.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Customers Also Viewed
C Y Hong et al.
Biochemical and biophysical research communications, 276(1), 278-285 (2000-09-28)
Norcantharidin (NCTD), a synthetic analogue of phosphatase type 2A inhibitors, cantharidin, was shown to have limited effects in treating human and animal tumors. The tumor cell killing mechanisms by norcantharidin, however, remain unclear. In this report, we wished to investigate
Norcantharidin modulates the miR-30a/Metadherin/AKT signaling axis to suppress proliferation and metastasis of stromal tumor cells in giant cell tumor of bone
Chen F, et al.
Biomedicine and Pharmacotherapy, 103, 1092-1100 (2018)
Chao-Bin Yeh et al.
PloS one, 7(2), e31055-e31055 (2012-03-01)
The rate of morbidity and mortality of hepatocellular carcinoma (HCC) in Taiwan has not lessened because of difficulty in treating tumor metastasis. Norcantharidin (NCTD) is currently used as an anticancer drug for hepatoma, breast cancer, and colorectal adenocarcinoma. NCTD possesses
Chung-Hsin Yeh et al.
Chinese journal of integrative medicine, 18(9), 676-682 (2012-09-01)
To investigate the inhibitory activities of norcantharidin (NCTD), a demethylated analogue of cantharidin, on Hep3B cells (a human hepatoma cell line) with deficiency of p53. The survival rate of the Hep3B cells after treating with NCTD was measured by MTT
Yu-Jen Chen et al.
PloS one, 7(5), e37006-e37006 (2012-05-23)
Multi-drug resistance (MDR), an unfavorable factor compromising treatment efficacy of anticancer drugs, involves upregulated ATP binding cassette (ABC) transporters and activated Sonic hedgehog (Shh) signaling. By preparing human breast cancer MCF-7 cells resistant to doxorubicin (DOX), we examined the effect
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