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M1004

Sigma-Aldrich

Met-Ala-Ser

≥97% (TLC)

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About This Item

Empirical Formula (Hill Notation):
C11H21N3O5S
CAS Number:
17351-33-6
Molecular Weight:
307.37
MDL number:
MFCD00055791
UNSPSC Code:
12352202
PubChem Substance ID:
24896466
NACRES:
NA.26

product name

Met-Ala-Ser,

Assay

≥97% (TLC)

form

powder

color

white

storage temp.

−20°C

SMILES string

CSCC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(O)=O

InChI

1S/C11H21N3O5S/c1-6(9(16)14-8(5-15)11(18)19)13-10(17)7(12)3-4-20-2/h6-8,15H,3-5,12H2,1-2H3,(H,13,17)(H,14,16)(H,18,19)/t6-,7-,8-/m0/s1

InChI key

WXHHTBVYQOSYSL-FXQIFTODSA-N

Amino Acid Sequence

Met-Ala-Ser

Application

Met-Ala-Ser has been used as a tripeptide in the OH radical-induced oxidation reaction and analysis by high performance liquid chromatography-diode array detector-fluorescence detector (HPLC-DAD-FLD).

Biochem/physiol Actions

Met-Ala-Ser (MAS) is used to complex with peptide deformylase(s) (PDF) to help delineate mechanisms of recognition of mimic-peptides by N-terminal cleaved expression peptide.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Release of free amino acids upon oxidation of peptides and proteins by hydroxyl radicals
Liu F, et al.
Analytical and Bioanalytical Chemistry, 409(9), 2411-2420 (2017)
Cong Han et al.
Biochemical and biophysical research communications, 319(4), 1292-1298 (2004-06-15)
Helicobacter pylori is a gram-negative pathogenic bacterium, which is associated with peptic ulcer disease and gastric cancer. It is urgent to discover novel drug targets for appropriate antimicrobial agents against this human pathogen. In bacteria, peptide deformylase (PDF) catalyzes the
Ki Hyun Nam et al.
Biochemical and biophysical research communications, 381(4), 630-633 (2009-03-03)
PDF (peptide deformylase) plays a critical role in the production of mature proteins by removing the N-formyl polypeptide of nascent proteins in the prokaryote cell system. This protein is essential for bacterial growth, making it an attractive target for the
A Becker et al.
Nature structural biology, 5(12), 1053-1058 (1998-12-10)
Eubacterial proteins are synthesized with a formyl group at the N-terminus which is hydrolytically removed from the nascent chain by the mononuclear iron enzyme peptide deformylase. Catalytic efficiency strongly depends on the identity of the bound metal. We have determined
Ren Miao et al.
Rapid communications in mass spectrometry : RCM, 19(8), 1031-1040 (2005-03-16)
Reactions of two platinum(II) complexes, cis-[Pt(NH3)2(H2O)2]2+ (Pt1) and cis-[Pt(en)(H2O)2]2+ (Pt2), with several sulfur-containing peptides, have been investigated by electrospray ionization mass spectrometry (ESI-MS) and tandem mass spectrometry (MS/MS). The species produced in the reactions were detected with ESI-MS, and MS/MS
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