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L6649

Sigma-Aldrich

Lonomycin A sodium salt from Streptomyces ribosidificus

90-95% (TLC)

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About This Item

Empirical Formula (Hill Notation):
C44H75NaO14
CAS Number:
58845-80-0
Molecular Weight:
851.05
Beilstein:
4122659
MDL number:
MFCD00133488
UNSPSC Code:
12352200
PubChem Substance ID:
329817642

Assay

90-95% (TLC)

storage temp.

2-8°C

SMILES string

[Na+].CO[C@H]1C[C@]2(CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H]4O[C@H]([C@H](OC)[C@@H]4C)[C@H]5O[C@](C)(O)[C@H](C)[C@@H](OC)[C@@H]5C)O[C@@H]([C@@H]1C)[C@@H](C)[C@H]6O[C@](O)([C@H](C)[C@@H](OC)[C@H]6C)[C@H](C)C([O-])=O

InChI

1S/C44H76O14.Na/c1-21-29(49-12)20-43(56-31(21)22(2)32-23(3)34(51-14)27(7)44(48,57-32)28(8)39(45)46)19-18-40(9,58-43)30-16-17-41(10,54-30)38-25(5)35(52-15)37(53-38)36-24(4)33(50-13)26(6)42(11,47)55-36;/h21-38,47-48H,16-20H2,1-15H3,(H,45,46);/q;+1/p-1/t21-,22-,23+,24+,25+,26-,27-,28-,29+,30-,31+,32-,33+,34+,35-,36+,37-,38-,40+,41+,42+,43-,44-;/m1./s1

InChI key

PIKGYGHAIOUQMF-SZCYNZSUSA-M

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Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301 + H311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
041H4028

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A Saito et al.
Parasitology research, 78(1), 28-31 (1992-01-01)
Obioactin, Lonomycin A, muramyl dipeptide, and scavengers of hydrogen radicals and of singlet oxygen were used to study the participation of.OH and 1O2 in the killing of Toxoplasma in cultures of glycogen-induced peritoneal macrophages. Both the scavengers of OH (diazabicyclooctane
K Tsuchida et al.
Japanese journal of pharmacology, 41(3), 353-361 (1986-07-01)
Effects of a K ionophore, lonomycin A (K+:Na+ = 6:1), on the action potential and contractile force in canine cardiac Purkinje fibers were examined. Lonomycin A increased the developed and resting tensions. The agent shortened the action potential, decreased the
H Seto et al.
The Journal of antibiotics, 33(9), 979-988 (1980-09-01)
All resonances observed in the 13C-nmr spectra of the polyether antibiotics lonomycin A and mutalomycin have been assigned by the aid of biosynthetic method, selective proton decoupling as well as comparison with structurally related compounds.
M Stoeck et al.
Journal of cellular physiology, 151(1), 8-12 (1992-04-01)
Murine thymocytes were stimulated with the protein kinase C activating agents Phorbol-12-myristate-13-acetate (PMA) or a more physiological membrane permeant diacylglycerol (dioctanoyl-sn-glycerol, DiC8) in the presence or absence of exogenous lymphokines (rIL-1 beta, rIL-2). Whereas PMA directly induced reactivity to rIL-2
M C Hillaire et al.
Reproduction, nutrition, development, 29(3), 247-257 (1989-01-01)
An in vitro study was carried out to evaluate the effect of different ionophore antibiotics and some of their derivatives on rumen fermentation and on the degradation of peanut meal nitrogen. The increase in the production of propionic acid at
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