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I151

Sigma-Aldrich

Indomethacin morpholinylamide

solid

Synonym(s):

BML-190, N-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetyl]morpholine

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About This Item

Empirical Formula (Hill Notation):
C23H23ClN2O4
Molecular Weight:
426.89
MDL number:
MFCD01317813
UNSPSC Code:
12352200
PubChem Substance ID:
329815352

form

solid

color

off-white

solubility

DMSO: >20 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

COc1ccc2n(c(C)c(CC(=O)N3CCOCC3)c2c1)C(=O)c4ccc(Cl)cc4

InChI

1S/C23H23ClN2O4/c1-15-19(14-22(27)25-9-11-30-12-10-25)20-13-18(29-2)7-8-21(20)26(15)23(28)16-3-5-17(24)6-4-16/h3-8,13H,9-12,14H2,1-2H3

InChI key

BJSDNVVWJYDOLK-UHFFFAOYSA-N

Gene Information

human ... CNR2(1269)

Biochem/physiol Actions

CB2 cannabinoid receptor agonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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E Romeo et al.
The Journal of pharmacology and experimental therapeutics, 262(3), 971-978 (1992-09-01)
The 2 aryl-3-indoleacetamides (FGIN-1) are a new class of compounds that potently (nM) and selectively bind to glial mitochondrial diazepam binding inhibitor (DBI) receptors (MDR), previously called peripheral benzodiazepine receptors, and increase mitochondrial steroidogenesis. The high-affinity binding of FGIN-1 to
Pretal P Muldoon et al.
Neuropharmacology, 176, 108170-108170 (2020-06-02)
Nicotine, the primary psychoactive component in tobacco, plays a major role in the initiation and maintenance of tobacco dependence and addiction, a leading cause of preventable death worldwide. An essential need thus exists for more effective pharmacotherapies for nicotine-use cessation.

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