HPA036774
Anti-NKX6-1 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-NK6 homeobox 1, Anti-NKX6A, Anti-Nkx6.1
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About This Item
Recommended Products
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500
immunogen sequence
PLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSM
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NKX6-1(4825)
Related Categories
General description
NKX6-1 (NK6 homeobox 1), a homeobox transcription factor is coded by NKX6A gene. It is located on human chromosome 4q21.2-q22. NKX6-1 belongs to the NK homeobox gene family. It is specific in adult cells producing insulin.
Immunogen
NK6 homeobox 1 recombinant protein epitope signature tag (PrEST)
Application
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-NKX6-1 antibody has been used in immunofluorescence, FAIRE (formaldehyde-assisted isolation of regulatory elements) and ChIP and immunohistochemistry.
Anti-NKX6-1 antibody has been used in immunofluorescence, FAIRE (formaldehyde-assisted isolation of regulatory elements) and ChIP and immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Chromatin immunoprecipitation (1 paper)
Chromatin immunoprecipitation (1 paper)
Biochem/physiol Actions
NKX6-1 (NK6 homeobox 1) is involved in the growth and modulation of endocrine activities of pancreatic islets. It acts as an immunohistochemical marker for pancreatic and duodenal neuroendocrine tumors. NKX6-1 also participates in lineage specification in early pancreatic progenitor tissue. This gene regulates the expression of several pancreas-related genes.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Linkage
Corresponding Antigen APREST80893
Physical form
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Minghui Wu et al.
Cell reports, 37(5), 109919-109919 (2021-11-04)
Type 2 diabetes mellitus (T2D) is a chronic age-related disorder characterized by hyperglycemia due to the failure of pancreatic beta cells to compensate for increased insulin demand. Despite decades of research, the pathogenic mechanisms underlying T2D remain poorly defined. Here
Generation of thalamic neurons from mouse embryonic stem cells.
Shiraishi A, et al.
Development, 144, 1211-1220 (2017)
Isolation, characterization, and chromosomal mapping of the human Nkx6. 1 gene (NKX6A), a new pancreatic islet homeobox gene.
Inoue H, et al.
Genomics, 40(2), 367-370 (1997)
Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6. 1 factors in IPC progenitors.
Walczak MP, et al.
Journal of Translational Medicine, 14(1), 341-341 (2016)
Duo An et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(2), E263-E272 (2017-12-28)
Cell encapsulation has been shown to hold promise for effective, long-term treatment of type 1 diabetes (T1D). However, challenges remain for its clinical applications. For example, there is an unmet need for an encapsulation system that is capable of delivering
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