E8126

Equilin

• Synonym(s): 1,3,5(10),7-Estratetraen-3-ol-17-one, 3-Hydroxy-1,3,5(10),7-estratetraen-17-one, 7-Dehydroestrone
• Empirical Formula (Hill Notation): C₁₈H₂₀O₂
• CAS Number: 474-86-2
• Molecular Weight: 268.35
• Beilstein: 2624302
• EC Number: 207-488-6
• MDL number: MFCD00046223
• UNSPSC Code: 12352200
• PubChem Substance ID: 24894666
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Quality Level: 100
• sterility: non-sterile
• Assay: ≥98% (HPLC)
• form: powder
• technique(s): inhibition assay: suitable
• mp: 238-240 °C (lit.)
• solubility: chloroform: methanol (1:1): 40 mg/mL, clear, colorless to faintly yellow
• shipped in: ambient
• storage temp.: room temp
• SMILES string: C[C@]12CC[C@H]3C(=CCc4cc(O)ccc34)[C@@H]1CCC2=O
• InChI: 1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3-5,10,14,16,19H,2,6-9H2,1H3/t14-,16+,18+/m1/s1
• InChI key: WKRLQDKEXYKHJB-HFTRVMKXSA-N

Description

Biochem/physiol Actions

Equilin is the Mare estrogen and is majorly used in multi-estrogen drugs for hormone replacement therapy.[1] It is synthesized in the microsomes of mare placenta.[2] It mediates estrogen receptor β (ERβ) expression resulting in the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) which favors monocytes adhesion in atherosclerosis.[3] In vitro equilin inhibits 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) that catalyzes the conversion of estrone to 17β-estradiol.[4]

Safety Information

• Pictograms: GHS08
• Signal Word: Warning
• Hazard Statements: H351,H361fd,H362
• Precautionary Statements: P202 - P260 - P263 - P264 - P270 - P308 + P313
• Hazard Classifications: Carc. 2 - Lact. - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves