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About This Item
Empirical Formula (Hill Notation):
C15H12I2O4
CAS Number:
Molecular Weight:
510.06
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
storage temp.
2-8°C
SMILES string
OC(=O)CCc1cc(I)c(Oc2ccc(O)cc2)c(I)c1
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Biochem/physiol Actions
DITPA, an analog of L-thyroxine, has inotropic but not chronotropic effects on heart muscle. It also stimulates myocardial angiogenesis after infarction by interaction with integrin αvཪ3 at the cell surface.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Saurin Raval
Expert opinion on therapeutic patents, 20(4), 593-596 (2010-03-03)
The patent application WO2008106213 describes the beneficial effects of thyroid hormone analogue 3,5 diiodothyropropionic acid (DITPA) such as stimulating weight loss in overweight mammals, lowering of triglyceride and treating metabolic syndrome in humans. The human population of the patients selected
Eugene Morkin et al.
Journal of molecular and cellular cardiology, 37(6), 1137-1146 (2004-12-02)
Thyroid hormone has the unique properties of lowering cholesterol in hypothyroid individuals and improving cardiac performance. Beginning in the 1950s, extensive efforts were made to develop thyroid hormone analogs that could utilize the cholesterol-lowering property in euthyroid individuals without affecting
Niranjan Maitra et al.
Journal of cardiovascular pharmacology, 50(5), 526-534 (2007-11-22)
We have used an oligonucleotide microarray to identify genes that are affected by congestive heart failure and those influenced by treatment with DITPA and DITPA in combination with captopril using a rat postinfarction model. The most striking result when comparing
Evelyn Heymann Schlenker et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 294(5), R1504-R1509 (2008-03-21)
In hypothyroid patients, altered microvascular structure and function may affect mood and cognitive function. We hypothesized that adult male hypothyroid rats will have significantly lower forebrain blood vessel densities (BVD) than euthyroid rats and that treatment with 3,5-diiothyroprionic acid (DITPA)
P W Ladenson et al.
The Journal of clinical endocrinology and metabolism, 95(3), 1349-1354 (2010-01-19)
Widespread thyroid hormone actions offer the possibility of developing selective thyromimetic analogs with salutary metabolic properties. Consequently, effects of diiodothyropropionic acid (DITPA) on body weight, serum lipoproteins, and bone metabolism markers were studied in a prospective, controlled, double-blind 24-wk trial
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