C4285
Acetyl-Calpastatin (184-210) human
~95% (HPLC), powder
Synonym(s):
Acetyl-Calpain inhibitor fragment 184-210, CS peptide
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About This Item
Empirical Formula (Hill Notation):
C142H230N36O44S
CAS Number:
Molecular Weight:
3177.63
MDL number:
UNSPSC Code:
12352200
Amino Acid Sequence
Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2
Biochem/physiol Actions
Inhibitor of calpain which induces an increase in secreted amyloid β-protein 1-42.
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Meredith Kohr Owen et al.
Circulation, 128(1), 9-18 (2013-05-21)
This investigation examined the mechanisms by which coronary perivascular adipose tissue (PVAT)-derived factors influence vasomotor tone and the PVAT proteome in lean versus obese swine. Coronary arteries from Ossabaw swine were isolated for isometric tension studies. We found that coronary
Amy L Strong et al.
Stem cells (Dayton, Ohio), 30(12), 2774-2783 (2012-09-13)
Adipose tissue maintains a subpopulation of cells, referred to as adipose-derived stromal/stem cells (ASCs), which have been associated with increased breast cancer tumorigenesis and metastasis. For ASCs to affect breast cancer cells, it is necessary to delineate how they mobilize
Tiziana Latronico et al.
PloS one, 8(2), e49656-e49656 (2013-02-08)
Proteolytic enzymes have been implicated in the pathogenesis of Multiple Sclerosis (MS) for both their ability to degrade myelin proteins and for their presence in MS plaques.In this study we investigated whether interferon-beta (IFN-β) could differently modulate the activity and
R Sharma et al.
Genetika, 49(4), 505-512 (2013-07-23)
The calpains and calpastatin (CAST) make up a major cytosolic proteolytic system, the calpain-calpastatin system, found in mammalian tissues. The relative levels of the components of the calpain-calpastatin system determine the extent of meat tenderization during postmortem storage. Calpastatin (CAST)
Samuele De Minicis et al.
Liver international : official journal of the International Association for the Study of the Liver, 32(10), 1574-1584 (2012-09-04)
Survival of hepatic stellate cells (HSCs) is a hallmark of liver fibrosis, while the induction of HSC apoptosis may induce recovery. Activated HSC are resistant to many pro-apoptotic stimuli. To this issue, the role of Endoplasmic Reticulum (ER) stress in
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