B5057
7-Benzyloxy-4-trifluoromethylcoumarin
≥99% (HPLC), solid
Synonym(s):
7-BFC
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5 MG
5.230,00 kr.
5.230,00 kr.
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5 MG
5.230,00 kr.
About This Item
Empirical Formula (Hill Notation):
C17H11F3O3
Molecular Weight:
320.26
MDL number:
UNSPSC Code:
12161501
PubChem Substance ID:
NACRES:
NA.47
5.230,00 kr.
Please contact Customer Service for Availability
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Product Name
7-Benzyloxy-4-trifluoromethylcoumarin, ≥99% (HPLC), solid
Quality Level
Assay
≥99% (HPLC)
form
solid
storage temp.
−20°C
SMILES string
FC(F)(F)C1=CC(=O)Oc2cc(OCc3ccccc3)ccc12
InChI
1S/C17H11F3O3/c18-17(19,20)14-9-16(21)23-15-8-12(6-7-13(14)15)22-10-11-4-2-1-3-5-11/h1-9H,10H2
InChI key
WVKLERKKJXUPIK-UHFFFAOYSA-N
Gene Information
rat ... Maoa(29253) , Maob(25750)
Application
7-Benzyloxy-4-trifluoromethylcoumarin has been used:
- in the SBAD2-3x-AAGLY hepatocyte-like cell (HLC) functional assay to measure the cytochrome P450 3A4 (CYP3A4)-dependent activity
- in O-dealkylation reaction to determine the activity of CYP3A
- to measure the activity of CYP3A-mediated 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase activity (BFCOD)
Biochem/physiol Actions
Metabolized primarily by cytochrome P450 isozymes CYP1A2 and CYP3A4.
Legal Information
Supplied by Gentest Corp., U.S. Patent Nos. 6,207,404.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Jiannan Ding et al.
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Elias M Oziolor et al.
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Scientific reports, 10(1), 17503-17503 (2020-10-17)
Hepatocytes are an important tool for in vitro toxicology testing. In addition to primary cultures, a limited number of immortalized cell lines have been developed. We here describe a new cell line, designated as HepaMN, which has been established from
Viktoriia Burkina et al.
Molecules (Basel, Switzerland), 25(11) (2020-06-14)
Water from wastewater treatment plants contains concentrations of pharmaceutically active compounds as high as micrograms per liter, which can adversely affect fish health and behavior, and contaminate the food chain. Here, we tested the ability of the common carp hepatic
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