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B3806

Sigma-Aldrich

Bisindolylmaleimide VIII acetate salt

≥93% (H-NMR)

Synonym(s):

Ro 31-7549 acetate

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About This Item

Empirical Formula (Hill Notation):
C24H22N4O2 · C2H4O2
CAS Number:
138516-31-1
Molecular Weight:
458.51
MDL number:
MFCD00909467
UNSPSC Code:
12352200

Assay

≥93% (H-NMR)

solubility

DMSO: soluble
H2O: soluble
methanol: soluble

storage temp.

−20°C

SMILES string

CC(O)=O.Cn1cc(C2=C(C(=O)NC2=O)c3cn(CCCN)c4ccccc34)c5ccccc15

InChI

1S/C24H22N4O2.C2H4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20;1-2(3)4/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30);1H3,(H,3,4)

InChI key

VEOXVBTXROWDAH-UHFFFAOYSA-N

Biochem/physiol Actions

Bisindolylmaleimide VIII acetate is a selective inhibitor of protein kinase C (PKC). Bisindolylmaleimide VIII acetate enhances Fas- and TRAIL-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.

Caution

Photosensitive

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
099K1076
049K1434
108K1754
108K1755
078K1223

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